Iridium Complex with Antiangiogenic Properties

Identified as nanomolar and selective inhibitor of receptor protein kinase VEGFR3 (Flt4), the nontoxic and octahedrally coordinated IrIII complex 1 was synthesized by a stereoselective oxidative addition to a square‐planar coordinated IrI precursor. The arrows in the image indicate positions at whic...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 49; no. 22; pp. 3839 - 3842
Main Authors Wilbuer, Alexander, Vlecken, Danielle H., Schmitz, Daan J., Kräling, Katja, Harms, Klaus, Bagowski, Christoph P., Meggers, Eric
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 17.05.2010
WILEY‐VCH Verlag
Subjects
angiogenesis
Animals
bioorganometallic chemistry
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Crystallography, X-Ray
Embryo, Nonmammalian
flt4/vegfr3
Humans
iridium
Iridium - chemistry
Models, Animal
Molecular Conformation
Neovascularization, Pathologic
Oxidation-Reduction
protein kinase inhibitor
Protein Kinase Inhibitors - chemistry
Protein Kinases - chemistry
Protein Kinases - metabolism
Stereoisomerism
Vascular Endothelial Growth Factor Receptor-3 - metabolism
Zebrafish
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Summary:Identified as nanomolar and selective inhibitor of receptor protein kinase VEGFR3 (Flt4), the nontoxic and octahedrally coordinated IrIII complex 1 was synthesized by a stereoselective oxidative addition to a square‐planar coordinated IrI precursor. The arrows in the image indicate positions at which the blood vessel formation in a zebrafish model of angiogenesis has been hampered by 1.
Bibliography:ArticleID:ANIE201000682
Financial support was provided by the DFG (FOR630).
istex:3499128ECD7B3A62B17586C4A8093C55530BC416
DFG - No. FOR630
ark:/67375/WNG-SXCB3PXR-G
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201000682