Recent advances in CE-MS: Synergy of wet chemistry and instrumentation innovations
CE with MS detection is a hyphenated technique which greatly improves the ability of CE to deal with real samples, especially with those coming from biology and medicine, where the target analytes are present as trace amounts in very complex matrices. CE‐MS is now almost a routine technique performe...
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Published in | Electrophoresis Vol. 32; no. 1; pp. 43 - 51 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.01.2011
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | CE with MS detection is a hyphenated technique which greatly improves the ability of CE to deal with real samples, especially with those coming from biology and medicine, where the target analytes are present as trace amounts in very complex matrices. CE‐MS is now almost a routine technique performed on commercially available instruments. It faces currently a tremendous development of the technique itself as well as of its wide application area. Great interest in CE‐MS is reflected in the scientific literature by many original research articles and also by numerous reviews. The review presented here has a general scope and belongs to a series of regularly published reviews on the topic. It covers the literature from the last 2 years, since January 2008 till June 2010. It brings a critical selection of related literature sorted into groups reflecting the main topics of actual scientific interest: (i) innovations in CE‐ESI‐MS, (ii) use of alternative interfaces, and (iii) ways to enhance sensitivity. Special attention is paid to novel electrolyte systems amenable to CE‐MS including nonvolatile BGEs, to advanced CE separation principles such as MEKC, MEEKC, chiral CE, and to the use of preconcentration techniques. |
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Bibliography: | Institutional Research Plan of the Academy of Sciences of the Czech Republic - No. AV0Z40310501 ark:/67375/WNG-BVS6R9FX-0 Grant Agency of the Czech Republic - No. 203/08/1536; No. P206/10/1219 Grant Agency of the Academy of Science of the Czech Republic - No. IAA 400310703 ArticleID:ELPS201000382 istex:BC2806B265BBADE3E43ECEBE3A4DF0531529D568 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0173-0835 1522-2683 1522-2683 |
DOI: | 10.1002/elps.201000382 |