Clinical and positron emission tomography of Parkinson's disease caused by LRRK2
We have recently identified mutations in a gene leucine‐rich repeat kinase–2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of...
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Published in | Annals of neurology Vol. 57; no. 3; pp. 453 - 456 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.03.2005
Willey-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | We have recently identified mutations in a gene leucine‐rich repeat kinase–2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of patients, including 6‐18F‐fluoro‐L‐dopa positron emission tomography and discuss the potential implications of this mutation, which alters a conserved residue in a domain required for kinase activation. Ann Neurol 2005;57:453–456 |
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Bibliography: | istex:2C945245C7DD6AA6498B34D7B63B1709044FCA83 ark:/67375/WNG-S32212B5-9 ArticleID:ANA20401 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0364-5134 1531-8249 |
DOI: | 10.1002/ana.20401 |