Perspective: machines for RNAi

• Published in: Genes & development Vol. 19; no. 5; pp. 517 - 529
• Main Authors: Tomari, Yukihide, Zamore, Phillip D
• Format: Journal Article
• Language: English
• Published: United States 01.03.2005
• Subjects: Animals; Down-Regulation - physiology; Humans; Protein Biosynthesis - physiology; RNA Stability - physiology; RNA, Messenger - metabolism; RNA, Small Interfering - metabolism; RNA-Binding Proteins - metabolism; Signal Transduction - physiology; Transcription, Genetic - physiology

RNA silencing pathways convert the sequence information in long RNA, typically double-stranded RNA, into approximately 21-nt RNA signaling molecules such as small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs and miRNAs provide specificity to protein effector complexes that repress mRNA t...