Perspective: machines for RNAi

RNA silencing pathways convert the sequence information in long RNA, typically double-stranded RNA, into approximately 21-nt RNA signaling molecules such as small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs and miRNAs provide specificity to protein effector complexes that repress mRNA t...

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Bibliographic Details
Published inGenes & development Vol. 19; no. 5; pp. 517 - 529
Main Authors Tomari, Yukihide, Zamore, Phillip D
Format Journal Article
LanguageEnglish
Published United States 01.03.2005
Subjects
Animals
Down-Regulation - physiology
Humans
Protein Biosynthesis - physiology
RNA Stability - physiology
RNA, Messenger - metabolism
RNA, Small Interfering - metabolism
RNA-Binding Proteins - metabolism
Signal Transduction - physiology
Transcription, Genetic - physiology
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Summary:RNA silencing pathways convert the sequence information in long RNA, typically double-stranded RNA, into approximately 21-nt RNA signaling molecules such as small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs and miRNAs provide specificity to protein effector complexes that repress mRNA transcription or translation, or catalyze mRNA destruction. Here, we review our current understanding of how small RNAs are produced, how they are loaded into protein complexes, and how they repress gene expression.
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ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1284105