Molecular Systems Architecture of Interactome in the Acute Myeloid Leukemia Microenvironment

A molecular systems architecture is presented for acute myeloid leukemia (AML) to provide a framework for organizing the complexity of biomolecular interactions. AML is a multifactorial disease resulting from impaired differentiation and increased proliferation of hematopoietic precursor cells invol...

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Bibliographic Details
Published inCancers Vol. 14; no. 3; p. 756
Main Authors Ayyadurai, V. A. Shiva, Deonikar, Prabhakar, McLure, Kevin G., Sakamoto, Kathleen M.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2022
MDPI
Subjects
Acute myeloid leukemia
Apoptosis
Bioinformatics
Biology
Bone cancer
Bone marrow
Bone tumors
Cell cycle
Cell interactions
Cell proliferation
Chemokines
Cytokines
Dendritic cells
Disease
Effector cells
Endothelial cells
Fibroblasts
Genes
Hemopoiesis
Immune system
Keywords
Kinases
Leukemia
Leukocytes
Literature reviews
Medical Subject Headings-MeSH
Mutation
Natural killer cells
Pathogenesis
Signal transduction
Stem cells
Stromal cells
Subject heading schemes
Suppressor cells
Systematic Review
Tumor microenvironment
systems biology
tumor microenvironment (TME)
CytoSolve
acute myeloid leukemia (AML)
immune cells
molecular systems architecture
leukemia stem cells (LSC)
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Summary:A molecular systems architecture is presented for acute myeloid leukemia (AML) to provide a framework for organizing the complexity of biomolecular interactions. AML is a multifactorial disease resulting from impaired differentiation and increased proliferation of hematopoietic precursor cells involving genetic mutations, signaling pathways related to the cancer cell genetics, and molecular interactions between the cancer cell and the tumor microenvironment, including endothelial cells, fibroblasts, myeloid-derived suppressor cells, bone marrow stromal cells, and immune cells (e.g., T-regs, T-helper 1 cells, T-helper 17 cells, T-effector cells, natural killer cells, and dendritic cells). This molecular systems architecture provides a layered understanding of intra- and inter-cellular interactions in the AML cancer cell and the cells in the stromal microenvironment. The molecular systems architecture may be utilized for target identification and the discovery of single and combination therapeutics and strategies to treat AML.
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These authors contributed equally to this work.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14030756