Definitive Local Therapy Is Associated with Improved Survival in Metastatic Soft Tissue Sarcomas

Definitive local therapy is often utilized in patients with metastatic soft tissue sarcomas (STS) to reduce morbidity associated with local tumor progression. We hypothesize that it is associated with improved overall survival (OS). Patients with newly diagnosed metastatic STS treated with chemother...

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Bibliographic Details
Published inCancers Vol. 13; no. 5; p. 932
Main Authors Reddy, Vishruth K, Jain, Varsha, Venigalla, Sriram, Nimgaokar, Vivek, Amurthur, Ashwin, Lee, Daniel Y, Sebro, Ronnie A, Maki, Robert G, Wilson, 2nd, Robert J, Weber, Kristy L, Shabason, Jacob E
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.02.2021
MDPI
Subjects
Abdomen
Cancer therapies
Chemotherapy
Medical prognosis
Metastases
Metastasis
Morbidity
Patients
Radiation therapy
Sarcoma
Surgery
Survival
Tumors
United States > US
local treatment
sarcoma
radiation
survival
surgery
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Summary:Definitive local therapy is often utilized in patients with metastatic soft tissue sarcomas (STS) to reduce morbidity associated with local tumor progression. We hypothesize that it is associated with improved overall survival (OS). Patients with newly diagnosed metastatic STS treated with chemotherapy were identified from the National Cancer Database and dichotomized into cohorts: 1. definitive local therapy (defined as either definitive dose radiotherapy, definitive surgery, or surgery with perioperative radiotherapy) or 2. conservative therapy (defined as systemic therapy with or without palliative therapy). The association between definitive local therapy and OS, and factors associated with the receipt of definitive local therapy were assessed. Total of 4180 patients were identified. Compared with the conservative therapy, receipt of any definitive local therapy was associated with improved OS (median 17.9 vs. 10.1 months). The survival benefit remained on multivariate analyses and propensity-score matched analyses, with a stepwise improvement with surgery and combined modality local therapy, specifically radiotherapy (HR: 0.77; < 0.001), surgery (HR: 0.67; < 0.001), and combined surgery and radiotherapy (HR: 0.42; < 0.001). Analysis of a large national cancer registry of patients with metastatic STS suggests that chemotherapy plus definitive local therapy is associated with a significant survival benefit compared to the standard chemotherapy alone.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13050932