The design strategy of intelligent biomedical magnesium with controlled-release platform

• Published in: Materials Science & Engineering C Vol. 97; pp. 254 - 263
• Main Authors: Bi, Yanze, Zhu, Xinyun, Zhao, Jianliang, Cui, Hanrui, Wang, Zhenguo, Li, Yan, Wang, Cai-qi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2019; Elsevier BV
• Subjects: Alginate; Alginates; Alginic acid; Animals; Biocompatible Materials - chemistry; Biodegradability; Biodegradation; Cell Line; Chitosan; Controlled release; Degradation; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; Drug Liberation; Fluorescent Dyes - pharmacokinetics; Hollow mesoporous silica; Indoles - chemistry; Iron; Magnesium; Magnesium - chemistry; Magnesium - pharmacokinetics; Materials science; Mice; Multilayers; Nanoparticles; Nanoparticles - chemistry; Organic chemistry; Polydopamine; Polymers - chemistry; Rhodamine 6G; Rhodamines - pharmacokinetics; Self-assembly; Silica; Silicon dioxide; Silicon Dioxide - chemistry; Spectroscopy, Fourier Transform Infrared; Stimuli; Toxicity Tests; X-Ray Diffraction; Polydopamine; Hollow mesoporous silica; Alginate; Magnesium; Chitosan; Controlled release
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2018.12.031

Magnesium has a very promising adhibition in biomedical field for its excellent mechanical and biodegradable properties, however, the intelligent applications of biomedical magnesium developed difficultly due to its characteristic degradation. A intelligent biomedical magnesium was constructed on magnesium (Mg) surface by incorporating polydopamine (PD) and mechanized hollow mesoporous silica nanoparticles (HMSs) as smart delivery platform nanocontainers. The supramolecular nanovalves of mechanized HMSs consisted of alginate/chitosan multilayers by self-assembly, which are capable of entrapping rhodamine 6G in the mesopores and can release the cargo under the chemical environment of alkali or Mg iron stimuli that correspond to the degradation of biomedical Mg. The alkali/Mg2+ dual stimuli-responsive release property of the HMSs endows the biodegradable Mg with controlled release potential. The well-designed smart delivery nanocontainers were combined with polydopamine deposited on Mg for excellent adhesion properties and positively charged amino group of PD. Furthermore, when the biomedical Mg with these mechanized HMSs was degraded in the simulated body environment, the alkali/Mg2+-triggered release of cargos from this smart delivery platform could bring a more functional application. [Display omitted] •A smart alkali/Mg2+ stimuli-responsive release platform was compound on biodegradable Mg.•Polydopamine was used to incorporate Mg and mechanized hollow mesoporous silica nanoparticles.•The seminal platform endows the biodegradable Mg with controlled release function.