TERT Promoter Alterations in Glioblastoma: A Systematic Review

Glioblastoma, the most frequent and aggressive primary malignant tumor, often presents with alterations in the telomerase reverse transcriptase promoter. Telomerase is responsible for the maintenance of telomere length to avoid cell death. Telomere lengthening is required for cancer cell survival an...

Full description

Saved in:
Bibliographic Details
Published inCancers Vol. 13; no. 5; p. 1147
Main Authors Olympios, Nathalie, Gilard, Vianney, Marguet, Florent, Clatot, Florian, Di Fiore, Frédéric, Fontanilles, Maxime
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.03.2021
MDPI
Subjects
Apoptosis
Biopsy
Brain cancer
Brain research
Cancer therapies
Cell cycle
Cell death
Cell survival
Chromosomes
Classification
Deoxyribonucleic acid
DNA
DNA methylation
Glioblastoma
Magnetic resonance imaging
Medical prognosis
Mutation
Plasma
RNA-directed DNA polymerase
Senescence
Systematic Review
Telomerase
Telomerase reverse transcriptase
Telomeres
Tumors
TERT
telomerase inhibition
glioblastoma
Online AccessGet full text

Cover

More Information
Summary:Glioblastoma, the most frequent and aggressive primary malignant tumor, often presents with alterations in the telomerase reverse transcriptase promoter. Telomerase is responsible for the maintenance of telomere length to avoid cell death. Telomere lengthening is required for cancer cell survival and has led to the investigation of telomerase activity as a potential mechanism that enables cancer growth. The aim of this systematic review is to provide an overview of the available data concerning alterations and glioblastoma in terms of incidence, physiopathological understanding, and potential therapeutic implications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13051147