A comprehensive protein expression profile of extracellular matrix biomaterial derived from porcine urinary bladder

To generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM). Tunica layers and muscularis mucosa were removed from bladders using mechanical delamination. UBM was prepared using a solution of peracetic acid in ethanol, l...

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Published inRegenerative medicine Vol. 7; no. 2; pp. 159 - 166
Main Authors Marçal, Helder, Ahmed, Tania, Badylak, Stephen F, Tottey, Stephen, Foster, L John R
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.03.2012
Subjects
Animals
Biocompatible Materials - metabolism
biomaterial
Biomedical materials
Bladder
ECM
Extracellular matrix
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - classification
Extracellular Matrix Proteins - metabolism
Health aspects
Male
Physiological aspects
Protein Transport
proteomics
Proteomics - methods
scaffold
Subcellular Fractions - metabolism
Sus scrofa - metabolism
tissue engineering
tissue regeneration
UBM
Urinary Bladder - metabolism
urinary bladder matrix
Australia
United States
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Abstract To generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM). Tunica layers and muscularis mucosa were removed from bladders using mechanical delamination. UBM was prepared using a solution of peracetic acid in ethanol, lyophilized then milled into powder. UBM biomaterial was subjected to tryptic digests and components separated using high-performance liquid chromatography with an ion trap mass spectrometer and identified through databases. A repertoire of 129 proteins with neurotrophic, antiangiogenic and tumor-suppressive activities and those associated with tissue remodeling and wound repair were identified. This study provides the first insight into the complex nature of the UBM and how its application may be tailored for specific applications in regenerative medicine. We propose that the UBM be further investigated for reconstructive and regenerative remodeling of cardiac and dermal tissues, as well as peripheral nerves.
AbstractList Aims: To generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM). Materials & methods: Tunica layers and muscularis mucosa were removed from bladders using mechanical delamination. UBM was prepared using a solution of peracetic acid in ethanol, lyophilized then milled into powder. UBM biomaterial was subjected to tryptic digests and components separated using high-performance liquid chromatography with an ion trap mass spectrometer and identified through databases. Results: A repertoire of 129 proteins with neurotrophic, antiangiogenic and tumor-suppressive activities and those associated with tissue remodeling and wound repair were identified. Conclusion: This study provides the first insight into the complex nature of the UBM and how its application may be tailored for specific applications in regenerative medicine. We propose that the UBM be further investigated for reconstructive and regenerative remodeling of cardiac and dermal tissues, as well as peripheral nerves.
To generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM). Tunica layers and muscularis mucosa were removed from bladders using mechanical delamination. UBM was prepared using a solution of peracetic acid in ethanol, lyophilized then milled into powder. UBM biomaterial was subjected to tryptic digests and components separated using high-performance liquid chromatography with an ion trap mass spectrometer and identified through databases. A repertoire of 129 proteins with neurotrophic, antiangiogenic and tumor-suppressive activities and those associated with tissue remodeling and wound repair were identified. This study provides the first insight into the complex nature of the UBM and how its application may be tailored for specific applications in regenerative medicine. We propose that the UBM be further investigated for reconstructive and regenerative remodeling of cardiac and dermal tissues, as well as peripheral nerves.
AIMSTo generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM).MATERIALS & METHODSTunica layers and muscularis mucosa were removed from bladders using mechanical delamination. UBM was prepared using a solution of peracetic acid in ethanol, lyophilized then milled into powder. UBM biomaterial was subjected to tryptic digests and components separated using high-performance liquid chromatography with an ion trap mass spectrometer and identified through databases.RESULTSA repertoire of 129 proteins with neurotrophic, antiangiogenic and tumor-suppressive activities and those associated with tissue remodeling and wound repair were identified.CONCLUSIONThis study provides the first insight into the complex nature of the UBM and how its application may be tailored for specific applications in regenerative medicine. We propose that the UBM be further investigated for reconstructive and regenerative remodeling of cardiac and dermal tissues, as well as peripheral nerves.
Audience Professional
Author Ahmed, Tania
Tottey, Stephen
Foster, L John R
Marçal, Helder
Badylak, Stephen F
AuthorAffiliation 2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
1Bio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. j.foster@unsw.edu.au
1Bio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
3Department of Surgery, University of Pittsburgh, Pittsburgh, PA 1521, USA
AuthorAffiliation_xml – name: 3Department of Surgery, University of Pittsburgh, Pittsburgh, PA 1521, USA
– name: 2McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
– name: 1Bio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. j.foster@unsw.edu.au
– name: 1Bio/Polymer Research Group, Centre for Advanced Macromolecular Design, School of Biotechnology & Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22397606$$D View this record in MEDLINE/PubMed
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Snippet To generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM). Tunica layers and...
Aims: To generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM). Materials &...
AIMSTo generate a comprehensive profile of the protein composition of xenogeneic biomaterial, derived from porcine urinary bladder matrix (UBM).MATERIALS &...
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StartPage 159
SubjectTerms Animals
Biocompatible Materials - metabolism
biomaterial
Biomedical materials
Bladder
ECM
Extracellular matrix
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - classification
Extracellular Matrix Proteins - metabolism
Health aspects
Male
Physiological aspects
Protein Transport
proteomics
Proteomics - methods
scaffold
Subcellular Fractions - metabolism
Sus scrofa - metabolism
tissue engineering
tissue regeneration
UBM
Urinary Bladder - metabolism
urinary bladder matrix
Title A comprehensive protein expression profile of extracellular matrix biomaterial derived from porcine urinary bladder
URI http://dx.doi.org/10.2217/rme.12.6
https://www.ncbi.nlm.nih.gov/pubmed/22397606
https://www.proquest.com/docview/926663445
https://search.proquest.com/docview/927692037
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