Adrenocorticotropin-related modulation of the human EEG and individual variability

During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied spontaneously within physiological ranges in eight healthy male volunteers (24.5±1.7 years), without pulsatile changes, correlation among variables, or i...

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Published inNeuroscience letters Vol. 262; no. 3; pp. 147 - 150
Main Authors Sannita, Walter G, Loizzo, Alberto, Garbarino, Sergio, Gesino, Diana, Massimilla, Simona, Ogliastro, Carla
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 12.03.1999
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Abstract During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied spontaneously within physiological ranges in eight healthy male volunteers (24.5±1.7 years), without pulsatile changes, correlation among variables, or indications of stress response. The power of the 6.5–14.0 Hz physiological `alpha' rhythm of the electroencephalogram (EEG) proved inverted-U correlated with the ACTH concentration (with maximum power at 12–14 pmol/l ACTH) but was independent from the extent of ACTH change or from cortisol/glucose concentrations. Two subgroups of subjects with low/high EEG power values could be separated depending on ACTH concentration, with estimated cut-off at 7–8 pmol/l. A direct ACTH modulation of brain electrophysiology or common factors (e.g. the corticotropin-releasing hormone) pacing both ACTH and EEG are suggested and may account for individual EEG differences.
AbstractList During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied spontaneously within physiological ranges in eight healthy male volunteers (24.5+/-1.7 years), without pulsatile changes, correlation among variables, or indications of stress response. The power of the 6.5-14.0 Hz physiological 'alpha' rhythm of the electroencephalogram (EEG) proved inverted-U correlated with the ACTH concentration (with maximum power at 12-14 pmol/l ACTH) but was independent from the extent of ACTH change or from cortisol/glucose concentrations. Two subgroups of subjects with low/high EEG power values could be separated depending on ACTH concentration, with estimated cut-off at 7-8 pmol/l. A direct ACTH modulation of brain electrophysiology or common factors (e.g. the corticotropin-releasing hormone) pacing both ACTH and EEG are suggested and may account for individual EEG differences.
During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied spontaneously within physiological ranges in eight healthy male volunteers (24.5±1.7 years), without pulsatile changes, correlation among variables, or indications of stress response. The power of the 6.5–14.0 Hz physiological `alpha' rhythm of the electroencephalogram (EEG) proved inverted-U correlated with the ACTH concentration (with maximum power at 12–14 pmol/l ACTH) but was independent from the extent of ACTH change or from cortisol/glucose concentrations. Two subgroups of subjects with low/high EEG power values could be separated depending on ACTH concentration, with estimated cut-off at 7–8 pmol/l. A direct ACTH modulation of brain electrophysiology or common factors (e.g. the corticotropin-releasing hormone) pacing both ACTH and EEG are suggested and may account for individual EEG differences.
During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied spontaneously within physiological ranges in eight healthy male volunteers (24.5 plus or minus 1.7 years), without pulsatile changes, correlation among variables, or indications of stress response. The power of the 6.5-14.0 Hz physiological `alpha' rhythm of the electroencephalogram (EEG) proved inverted-U correlated with the ACTH concentration (with maximum power at 12-14 pmol/l ACTH) but was independent from the extent of ACTH change or from cortisol/glucose concentrations. Two subgroups of subjects with low/high EEG power values could be separated depending on ACTH concentration, with estimated cut-off at 7-8 pmol/l. A direct ACTH modulation of brain electrophysiology or common factors (e.g. the corticotropin-releasing hormone) pacing both ACTH and EEG are suggested and may account for individual EEG differences.
Author Garbarino, Sergio
Gesino, Diana
Sannita, Walter G
Loizzo, Alberto
Massimilla, Simona
Ogliastro, Carla
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Issue 3
Keywords Adrenocorticotropic hormone
Blood concentrations
Healthy volunteers
Quantitative electroencephalogram
Cortisol
Individual variability
Glucose
Human
Adenohypophyseal hormone
Adrenal hormone
Interindividual comparison
Electrophysiology
Electroencephalography
Hydrocortisone
Glucocorticoid
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Snippet During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied...
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SubjectTerms Adrenocorticotropic hormone
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - physiology
Adult
Alpha Rhythm
Biological and medical sciences
Blood concentrations
Blood Glucose - metabolism
Brain - physiology
Cortisol
Electroencephalography
Fundamental and applied biological sciences. Psychology
Glucose
Healthy volunteers
Hormones and neuropeptides. Regulation
Humans
Hydrocortisone - blood
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Individual variability
Male
Organ Specificity
Quantitative electroencephalogram
Time Factors
Vertebrates: endocrinology
Title Adrenocorticotropin-related modulation of the human EEG and individual variability
URI https://dx.doi.org/10.1016/S0304-3940(99)00078-6
https://www.ncbi.nlm.nih.gov/pubmed/10218877
https://search.proquest.com/docview/17304862
https://search.proquest.com/docview/69715060
Volume 262
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