Adrenocorticotropin-related modulation of the human EEG and individual variability

During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied spontaneously within physiological ranges in eight healthy male volunteers (24.5±1.7 years), without pulsatile changes, correlation among variables, or i...

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Published inNeuroscience letters Vol. 262; no. 3; pp. 147 - 150
Main Authors Sannita, Walter G, Loizzo, Alberto, Garbarino, Sergio, Gesino, Diana, Massimilla, Simona, Ogliastro, Carla
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 12.03.1999
Elsevier
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Summary:During a 6-h period in resting conditions, the blood concentrations at rest of cortisol, glucose and the adrenocorticotropic hormone (ACTH) varied spontaneously within physiological ranges in eight healthy male volunteers (24.5±1.7 years), without pulsatile changes, correlation among variables, or indications of stress response. The power of the 6.5–14.0 Hz physiological `alpha' rhythm of the electroencephalogram (EEG) proved inverted-U correlated with the ACTH concentration (with maximum power at 12–14 pmol/l ACTH) but was independent from the extent of ACTH change or from cortisol/glucose concentrations. Two subgroups of subjects with low/high EEG power values could be separated depending on ACTH concentration, with estimated cut-off at 7–8 pmol/l. A direct ACTH modulation of brain electrophysiology or common factors (e.g. the corticotropin-releasing hormone) pacing both ACTH and EEG are suggested and may account for individual EEG differences.
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ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(99)00078-6