An efficient green synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives via Strecker reaction under controlled microwave heating

• Published in: Green processing and synthesis Vol. 8; no. 1; pp. 297 - 301
• Main Authors: Sadek, Kamal Usef, Abdel-Hameed, Afaf Mohamed, Abdelnabi, Hisham A., Meleigy, Yasser
• Format: Journal Article
• Language: English
• Published: Berlin De Gruyter 28.01.2019; Walter de Gruyter GmbH
• Subjects: [1,2,4]triazoles; Aldehydes; catalyst free; Chemical synthesis; Cyanides; Derivatives; Heating; imidazo [1,2; imidazo [1,2-a]imidazoles; imidazo[2,1; imidazo[2,1-c][1,2,4]triazoles; Imidazole; imidazoles; Microwave heating; multi-component reaction; Pyridines; Reaction time; Strecker reaction; Triazoles
• ISSN: 2191-9542; 2191-9550; 2191-9550
• DOI: 10.1515/gps-2018-0093

A highly efficient multi-component one-pot synthesis of novel 1 -imidazo[1,2- ]imidazole-3-amine and imidazo[2,1- ][1,2,4]triazole-5-amine derivatives has been developed through the reaction of easily available aromatic aldehydes, benzoyl cyanide and either 2-aminoimidazole-4,5-dicarbonitrile or 3-amino-1,2,4-triazole in pyridine under controlled microwave heating. The process is environmentally friendly, is operationally simple, with short reaction time and with high yields.