Colorectal cancer and 18FDG-PET/CT：What about adding the T to the N parameter in loco-regional staging

• Published in: World journal of gastroenterology : WJG Vol. 17; no. 11; pp. 1427 - 1433
• Main Authors: Mainenti, Pier Paolo, Iodice, Delfina, Segreto, Sabrina, Storto, Giovanni, Magliulo, Mario, De Palma, Giovanni Domenico, Salvatore, Marco, Pace, Leonardo
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 21.03.2011
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - diagnostic imaging; Adenocarcinoma - pathology; Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - diagnostic imaging; Colorectal Neoplasms - pathology; CT图像; Female; Fluorodeoxyglucose F18; Humans; Logistic Models; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Original; PET; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Tomography, X-Ray Computed; 可信区间; 大肠癌; 局部区域; 平均年龄; 正电子发射断层扫描; 计算机断层扫描; Colorectal; Staging; Positron emission tomography/computed tomography; Cancer
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i11.1427

AIM：To evaluate whether FDG-positron emission tomography（PET）/computed tomography（CT）may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.METHODS：Thirty four consecutive patients（20 men and 14 women;mean age：63 years）with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study.All patients underwent FDG-PET/CT preoperatively.The primary tumor site and extent were evaluated on PET/CT images.Colorectal wall invasion was analysed according to a modified T classification that considers only three stages（≤T2,T3,T4）.Assessment of accuracy was carried out using 95%confidence intervals for T.RESULTS：Thirty five/37（94.6%）adenocarcinomas were identified and correctly located on PET/CT images.PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3%（95%CI：87%-100%）.All T1,T3 and T4 lesions were correctly staged,while two T2 neoplasms were overstated as T3.CONCLUSION：Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer.