Association study of the endothelial nitric oxide synthase gene polymorphisms with essential hypertension in northern Han Chinese

• Published in: Chinese medical journal Vol. 119; no. 13; pp. 1065 - 1071
• Main Authors: Zhao, Qi, Su, Shao-yong, Chen, Shu-feng, Li, Biao, Gu, Dong-feng
• Format: Journal Article
• Language: English
• Published: China Division of Population Genetics and Prevention, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China 05.07.2006; National Human Genome Center at Beijing, Beijing 100176, China%Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
• Subjects: Adult; Aged; China - ethnology; Female; Haplotypes; Humans; Hypertension - enzymology; Hypertension - genetics; Male; Middle Aged; Nitric Oxide Synthase Type III - genetics; Polymorphism, Genetic; 一氧化氮; 基因多态性; 高血压; China; endothelial nitric oxide synthase; haplotype; single nucleotide polymorphism; hypertension; case-control studies
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/00029330-200607010-00002

Background Nitric oxide （NO） synthesized by endothelial nitric oxide synthase （eNOS） plays an important role in both the regulation of endothelial function and the control of blood pressure. Up to now, there has been conflicting data regarding the association between three clinically relevant polymorphisms （T-786C, intron4b/a and G894T） of the eNOS gene and essential hypertension.