Molecular regulation of visual system development: more than meets the eye

Vertebrate eye development has been an excellent model system to investigate basic concepts of developmental biology ranging from mechanisms of tissue induction to the complex patterning and bidimensional orientation of the highly specialized retina. Recent advances have shed light on the interplay...

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Bibliographic Details
Published inGenes & development Vol. 21; no. 4; pp. 367 - 378
Main Authors Harada, Takayuki, Harada, Chikako, Parada, Luis F
Format Journal Article
LanguageEnglish
Published United States 15.02.2007
Subjects
Animals
Cell Polarity
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiology
Ephrins - metabolism
Eye - anatomy & histology
Eye - growth & development
Eye - metabolism
Humans
Optic Chiasm - cytology
Optic Chiasm - growth & development
Optic Chiasm - metabolism
Retina - cytology
Retina - growth & development
Retina - metabolism
Retinal Ganglion Cells - cytology
Retinal Ganglion Cells - metabolism
Thalamus - anatomy & histology
Thalamus - physiology
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Summary:Vertebrate eye development has been an excellent model system to investigate basic concepts of developmental biology ranging from mechanisms of tissue induction to the complex patterning and bidimensional orientation of the highly specialized retina. Recent advances have shed light on the interplay between numerous transcriptional networks and growth factors that are involved in the specific stages of retinogenesis, optic nerve formation, and topographic mapping. In this review, we summarize this recent progress on the molecular mechanisms underlying the development of the eye, visual system, and embryonic tumors that arise in the optic system.
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ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1504307