Genetic pathways and histogenetic models of AIDS-related lymphomas

• Published in: European journal of cancer (1990) Vol. 37; no. 10; pp. 1270 - 1275
• Main Authors: Carbone, A, Gloghini, A, Capello, D, Gaidano, G
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.07.2001; Elsevier
• Subjects: AIDS; Biological and medical sciences; Burkitt Lymphoma - genetics; Carcinogenesis, carcinogens and anticarcinogens; Epstein-Barr Virus Infections - genetics; Histogenesis; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Lymphoma, AIDS-Related - genetics; Lymphoma, Non-Hodgkin - genetics; Lymphomas; Medical sciences; Nervous System Neoplasms - immunology; Pathogenesis; Tumors; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viruses; AIDS; Lymphomas; Histogenesis; Pathogenesis; Gammaherpesvirinae; Human; Immunopathology; Herpesviridae; Cell biology; Malignant hemopathy; Histology; Epstein Barr virus; Carcinogenesis; Genetic determinism; Immune deficiency; Lymphoma; Modeling; Infection; Virus; Phenotype; Lymphoproliferative syndrome; Viral disease; Risk factor
• ISSN: 0959-8049; 1879-0852
• DOI: 10.1016/S0959-8049(01)00119-8

Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.