Optical Molecular Imaging Frontiers in Oncology： The Pursuit of Accuracy and Sensitivity

• Published in: Engineering (Beijing, China) Vol. 1; no. 3; pp. 309 - 323
• Main Authors: Wang, Kun, Chi, Chongwei, Hu, Zhenhua, Liu, Muhan, Hui, Hui, Shang, Wenting, Peng, Dong, Zhang, Shuang, Ye, Jinzuo, Liu, Haixiao, Tian, Jie
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2015; Elsevier
• Subjects: Cerenkov luminescence imaging; intraoperative image-guided surgery; multimodality molecular imaging; optical molecular imaging; optical multimodality tomography; 光学图像; 准确度; 分子影像学; 分子成像; 尖端技术; 成像方法; 灵敏度; 肿瘤; intraoperative image-guided surgery; multimodality molecular imaging; Cerenkov luminescence imaging; optical molecular imaging; optical multimodality tomography
• ISSN: 2095-8099
• DOI: 10.15302/J-ENG-2015082

Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Cerenkov luminescence imaging （CLI）, and optical image- guided surgeries. New abilities allow in vivo cancer imaging with sensitivity and accuracy that are unprecedented in conventional imaging approaches. The visualization of cellular and molecular behaviors and events within tumors in living subjects is improving our deeper understanding of tumors at a systems level. These advances are being rapidly used to acquire tumor-to-tumor molecular heterogeneity, both dynamically and quantitatively, as well as to achieve more effective therapeutic interventions with the assistance of real-time imaging. In the era of molecular imaging, optical technologies hold great promise to facilitate the development of highly sensitive cancer diagnoses as well as personalized patient treatment--one of the ultimate goals of precision medicine.