Effect of Fermented Sarco Oyster ( Crassostrea gigas ) Extract on Muscle Strength Enhancement in Postmenopausal Females: A Randomized, Double-Blind, Placebo-Controlled Trial

• Published in: International journal of environmental research and public health Vol. 19; no. 24; p. 16450
• Main Authors: Rheu, Kyoung-Min, Lee, Bae-Jin, Son, Woo-Hyeon, Kim, Dong-Seok, Park, Hyun-Tae, Ha, Min-Seong, Gong, Byong-Hak, Jeon, Byeong-Hwan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.12.2022; MDPI
• Subjects: Angular velocity; Animals; Blood; Body Composition; C-reactive protein; Chemistry; Clinical trials; Crassostrea; Creatinine; Dietary Supplements; Double-Blind Method; Double-blind studies; Female; Females; Grip strength; Growth factors; Hand Strength; Humans; Immunoassay; Insulin; Insulin-like growth factor I; Insulin-like growth factors; Lactic acid; Muscle function; Muscle Strength; Muscle, Skeletal - physiology; Musculoskeletal system; Oysters; Placebos; Post-menopause; Postmenopause - physiology; Proteins; Pyruvic acid; Quadriceps muscle; Quality of life; Questionnaires; Sarcopenia; Velocity; Womens health; South Korea; Germany; muscle strength; postmenopausal female; γ-aminobutyric acid; dietary supplements; fermented oyster; insulin growth factor-1; sarcopenia
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph192416450

A randomized controlled trial (RCT) was conducted to evaluate the effect of fermented sarco oysters (FSO) on muscle strength in postmenopausal females with low muscle mass. Fifty-two female participants were randomly divided into the experiment group (EG) or control group (CG). For 12 weeks, the EG was subjected to 1000 mg of FSO extract daily while the CG consumed the placebo extract. The muscle extension and flexion at an angular velocity of 60°/s and with respect to grip strength, body composition, and muscle growth-related blood factors were measured at the baseline and after the trial. The difference in the quadriceps muscle extension at an angular velocity of 60°/s, grip strength on both the left and right side, and insulin-like growth factor-1(IGF-1) between groups were significantly higher in the EG compared with the CG. However, no differences were found in body composition, blood pyruvate, lactate, or high-sensitivity C-reactive protein (hsCRP) concentration between the two groups. In conclusion, FSO supplements may improve muscle strength in postmenopausal females with relatively reduced muscle strength without a change in muscle mass.