The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity

• Published in: Brain (London, England : 1878) Vol. 147; no. 4; pp. 1423 - 1435
• Main Authors: Lefebvre, Stephanie, Gehrig, Gwendolyn, Nadesalingam, Niluja, Nuoffer, Melanie G, Kyrou, Alexandra, Wüthrich, Florian, Walther, Sebastian
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 04.04.2024
• Subjects: Cross-Sectional Studies; Evoked Potentials, Motor - physiology; Humans; Neural Inhibition - physiology; Original; Parietal Lobe; Psychotic Disorders; Schizophrenia; Transcranial Magnetic Stimulation - methods; catatonia; SICI; motor inhibition; resting-state fMRI; diffusion imaging
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/awad395

Abstract Psychomotor slowing is a frequent symptom of schizophrenia. Short-interval intracortical inhibition assessed by transcranial magnetic stimulation demonstrated inhibitory dysfunction in schizophrenia. The inhibitory deficit results from additional noise during information processing in the motor system in psychosis. Here, we tested whether cortical inhibitory dysfunction was linked to psychomotor slowing and motor network alterations. In this cross-sectional study, we included 60 patients with schizophrenia and psychomotor slowing determined by the Salpêtrière Retardation Rating Scale, 23 patients without slowing and 40 healthy control participants. We acquired single and double-pulse transcranial magnetic stimulation effects from the left primary motor cortex, resting-state functional connectivity and diffusion imaging on the same day. Groups were compared on resting motor threshold, amplitude of the motor evoked potentials, as well as short-interval intracortical inhibition. Regression analyses calculated the association between motor evoked potential amplitudes or cortical inhibition with seed-based resting-state functional connectivity from the left primary motor cortex and fractional anisotropy at whole brain level and within major motor tracts. In patients with schizophrenia and psychomotor slowing, we observed lower amplitudes of motor evoked potentials, while the short-interval intracortical inhibition/motor evoked potentials amplitude ratio was higher than in healthy controls, suggesting lower cortical inhibition in these patients. Patients without slowing also had lower amplitudes of motor evoked potentials. Across the combined patient sample, cortical inhibition deficits were linked to more motor coordination impairments. In patients with schizophrenia and psychomotor slowing, lower amplitudes of motor evoked potentials were associated with lower fractional anisotropy in motor tracts. Moreover, resting-state functional connectivity between the primary motor cortex, the anterior cingulate cortex and the cerebellum increased with stronger cortical inhibition. In contrast, in healthy controls and patients without slowing, stronger cortical inhibition was linked to lower resting-state functional connectivity between the left primary motor cortex and premotor or parietal cortices. Psychomotor slowing in psychosis is linked to less cortical inhibition and aberrant functional connectivity of the primary motor cortex. Higher neural noise in the motor system may drive psychomotor slowing and thus may become a treatment target.Lefebvre et al. demonstrate that psychomotor slowing in psychosis is linked to less cortical inhibition and aberrant functional connectivity of the primary motor cortex. They conclude that higher levels of neural noise in the motor system may drive psychomotor slowing and could represent a potential treatment target.