RNA interference as a novel and powerful tool in immunopharmacological research

RNA interference (RNAi), as an evolutionarily conserved mechanism for silencing gene expression, is realized through the actions of both small interference RNA (siRNA) and microRNA. Since its discovery, siRNA has been rapidly deployed not only for the elucidation of gene function, but also for ident...

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Published inInternational immunopharmacology Vol. 7; no. 4; pp. 417 - 426
Main Authors Kong, Yan, Ruan, Lingfei, Ma, Lili, Cui, Youhong, Wang, Ji Ming, Le, Yingying
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.04.2007
Elsevier
Subjects
Animals
Biological and medical sciences
Drug Design
Gene Targeting
Humans
Immune system
Immune System Diseases - drug therapy
Immune System Diseases - immunology
Medical sciences
Pharmacology. Drug treatments
RNA Interference
RNA, Small Interfering - pharmacology
siRNA
Therapeutics
dsRNA
RISC
RNAi
PEG
RNA interference
shRNA
PILs
MREs
Therapeutics
miRNA
siRNA
Immune system
Gene silencing
Treatment
Small Interference RNA
Research
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Summary:RNA interference (RNAi), as an evolutionarily conserved mechanism for silencing gene expression, is realized through the actions of both small interference RNA (siRNA) and microRNA. Since its discovery, siRNA has been rapidly deployed not only for the elucidation of gene function, but also for identification of drug targets and as a powerful therapeutic approach for a variety of diseases. In this review, we briefly introduce the mechanisms of RNAi, methods of siRNA design and delivery, and summarized recent researches on the therapeutic potential of RNAi for immune diseases.
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ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2006.12.011