Uremic lung: new insights into a forgotten condition

The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulat...

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Bibliographic Details
Published inKidney international Vol. 74; no. 7; pp. 849 - 851
Main Authors Scheel, Paul J., Liu, Manchang, Rabb, Hamid
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2008
Elsevier Limited
Subjects
Acute Kidney Injury - complications
Acute Kidney Injury - mortality
Animals
Cytokines
Humans
Immune System
Inflammation
Lung Diseases - etiology
Lung Diseases - pathology
Uremia - complications
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Summary:The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-2
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ISSN:0085-2538
1523-1755
DOI:10.1038/ki.2008.390