Cadmium concentration in maternal and cord blood and infant birth weight: a study on healthy non-smoking women

• Published in: Journal of perinatal medicine Vol. 30; no. 5; pp. 395 - 399
• Main Authors: Salpietro, C. D., Gangemi, S., Minciullo, P. L., Briuglia, S., Merlino, M. V., Stelitano, A., Cristani, M., Trombetta, D., Saija, A.
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter 01.01.2002; New York, NY De Gruyter
• Subjects: Biological and medical sciences; Birth Weight; Cadmium - blood; Diet; Female; Fetal Blood - chemistry; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Male; Management. Prenatal diagnosis; Medical sciences; Pregnancy; Pregnancy. Fetus. Placenta; Reference Values; Smoking; Pregnancy; Human; Non smoker; Cadmium; Healthy subject; Mother; Birth weight; Umbilical cord; Blood; Quantitative analysis
• ISSN: 0300-5577; 1619-3997
• DOI: 10.1515/JPM.2002.061

The aim of our study was to measure, at delivery, maternal and cord blood cadmium levels (by means of atomic absorption spectrometry) in 45 healthy non-smoking pregnant women exposed to a low cadmium challenge, and to evaluate the relationship between these cadmium levels and the birth weight of the infants. Our results showed fairly low cadmium levels in maternal blood, in accordance with the fact that all women enrolled in this study lived in areas with low toxic metal contamination and that they did not smoke during their pregnancy. Furthermore, a highly significant direct correlation was found between maternal and cord blood cadmium concentrations. Since cadmium concentration appeared of the same order of magnitudine both in cord and maternal serum, one could speculate that cadmium is transferred easily from the mother to the fetus through the placenta. Finally, we found that birth weight is inversely correlated with maternal and cord blood cadmium concentrations; thus birth weight might be negatively influenced by cadmium levels as a result of the toxic effects of the metal on the placenta. Although preliminary, our data show that (also not-predictable) prenatal exposure to even low cadmium levels might be a risk factor for developmental impairment in infants.