Clinical Study of Bone Regeneration by Conditioned Medium From Mesenchymal Stem Cells After Maxillary Sinus Floor Elevation

This clinical study was undertaken to evaluate the safety of use of the secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) for maxillary sinus floor elevation (SFE). MSC-CM was prepared from conditioned medium from human bone marrow-derived MSCs. Six partially edentulous patients were...

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Published inImplant dentistry Vol. 26; no. 4; p. 607
Main Authors Katagiri, Wataru, Watanabe, Junna, Toyama, Naoto, Osugi, Masashi, Sakaguchi, Kohei, Hibi, Hideharu
Format Journal Article
LanguageEnglish
Published United States 01.08.2017
Subjects
Biopsy
Bone Regeneration - physiology
Calcium Phosphates - pharmacology
Culture Media, Conditioned - pharmacology
Dental Implantation, Endosseous - methods
Dental Implants
Female
Humans
Jaw, Edentulous, Partially - surgery
Male
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stromal Cells - physiology
Middle Aged
Sinus Floor Augmentation
Tissue Scaffolds
Tomography, X-Ray Computed
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Summary:This clinical study was undertaken to evaluate the safety of use of the secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) for maxillary sinus floor elevation (SFE). MSC-CM was prepared from conditioned medium from human bone marrow-derived MSCs. Six partially edentulous patients were enrolled in the study. MSC-CM was mixed with porous beta-tricalcium phosphate (β-TCP) and implanted in 4 patients (experimental group), whereas only β-TCP was implanted in the other 2 patients (control group). Six months after SFE, bone biopsies and histological assessments were performed. Bone formation was clinically confirmed in all cases. Although Hounsfield units in computed tomography images were not significantly different between the groups, histological analysis revealed a significant difference in newly formed bone area between the groups. In particular, bone volume in the center of the augmented area was significantly greater in the MSC-CM group. Newly formed bone consisted of lamellar bone in the MSC-CM group but woven bone in the β-TCP group. The secretome of bone marrow-derived mesenchymal stem cells (MSC-CM) was used safely and has great osteogenic potential for regenerative medicine of bone.
ISSN:1538-2982
DOI:10.1097/id.0000000000000618