Telomerase Activity in Benign and Malignant Breast Lesions: a Pilot Prospective Study on Fine-Needle Aspirates

Villa et al prospectively assessed the diagnostic accuracy of findings of telomerase activity in a consecutive series of fine-needle aspirates from 116 solid breast lesions that were subsequently submitted for histologic examination.

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 90; no. 7; pp. 537 - 539
Main Authors Villa, Raffaella, Zaffaroni, Nadia, Folini, Marco, Daidone, Maria Grazia, Silvestrini, Rosella, Martelli, Gabriele, Palo, Giuseppe De
Format Journal Article
LanguageEnglish
Published Cary, NC Oxford University Press 01.04.1998
Oxford Publishing Limited (England)
Subjects
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy, Needle
Breast cancer
Breast Diseases - enzymology
Breast Neoplasms - enzymology
Carcinoma - enzymology
Enzymes
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical research
Medical sciences
Middle Aged
Pilot Projects
Polymerase Chain Reaction - methods
Prospective Studies
Repetitive Sequences, Nucleic Acid
Sensitivity and Specificity
Telomerase - metabolism
Tumors
Human
Malignant tumor
Experimental study
Gene expression
Telomere
Differential diagnostic
Mammary gland diseases
Enzymatic activity
Decision aid
Female
Mammary gland
Benign neoplasm
Comparative study
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Summary:Villa et al prospectively assessed the diagnostic accuracy of findings of telomerase activity in a consecutive series of fine-needle aspirates from 116 solid breast lesions that were subsequently submitted for histologic examination.
Bibliography:istex:42193CEC60B4773F611D20798E8CA1FFF3BEB269
ark:/67375/HXZ-JNFBJ8GC-R
Supported by grants from the Associazione Italiana per la Ricerca sul Cancro and the Italian National Research Council (grant no. 97.00490. CT04).
Correspondence to: Rosella Silvestrini, Ph.D., Oncologia Sperimentale C, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.
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ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/90.7.537