Possible treatment of circadian sleep disorders using daily ketotifen administration

Classic H 1 histamine receptor (H 1 R) antagonists are currently used as over-the-counter sleep aids. However, their overdose administrations rather produce wakefulness. Our previous rat model studies suggest that ketotifen, an early-phase, second-generation H 1 R antagonist may be a more desirable...

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Bibliographic Details
Published inSleep and biological rhythms Vol. 14; no. 1; pp. 117 - 120
Main Authors Ahmad, Alsawaf, Takeuchi, Kouhei, Ozaki, Tomoya, Unno, Katsuya, Mohammad, Shahid, Akechi, Honami, Morioka, Eri, Honda, Kazuki, Ikeda, Masayuki
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.01.2016
Subjects
Biomedical and Life Sciences
Biomedicine
Health Psychology
Human Physiology
Internal Medicine
Neurology
Neurosciences
Psychiatry
Short Paper
Circadian clock
Behavioral feedback
Sleep-induced phase shifts
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Summary:Classic H 1 histamine receptor (H 1 R) antagonists are currently used as over-the-counter sleep aids. However, their overdose administrations rather produce wakefulness. Our previous rat model studies suggest that ketotifen, an early-phase, second-generation H 1 R antagonist may be a more desirable sleep aid. Here, we further examined daily injections of ketotifen (3 mg/kg, intraperitoneally, for 5 days) 3 h before light onset time in rats and analyzed the effect of ketotifen on the successive free-running locomotor activity rhythms under constant dim red light. We found significant phase-advancement by the daily ketotifen injections, suggesting possible treatment of circadian sleep disorders using daily ketotifen administration.
ISSN:1446-9235
1479-8425
DOI:10.1007/s41105-015-0021-y