Risk factors influencing clinical outcome in Staphylococcus aureus bacteraemia in a Turkish University Hospital

• Published in: International journal of antimicrobial agents Vol. 14; no. 1; pp. 57 - 63
• Main Authors: Topeli, Arzu, Ünal, Serhat, Akalin, H.Erdal
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 01.02.2000; Amsterdam Elsevier; New York, NY
• Subjects: Adult; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteraemia; Bacteremia - microbiology; Bacteremia - mortality; Biological and medical sciences; Female; Hospitals, University; Humans; Male; Medical sciences; Methicillin - pharmacology; Methicillin Resistance; Methicillin-resistant Staphylococcus aureus; Middle Aged; Mortality; Pharmacology. Drug treatments; Prognosis; Risk Factors; Staphylococcal Infections - microbiology; Staphylococcal Infections - mortality; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - isolation & purification; Turkey; Turkey - epidemiology; Asia; Turkey; Bacteraemia; Mortality; Methicillin-resistant Staphylococcus aureus; Staphylococcus aureus; β-Lactams; Meticillin; Infection; Penicillin derivatives; Resistance; Antibiotic; Risk factor; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Hospital; Antibacterial agent
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/S0924-8579(99)00147-8

A total of 101 episodes of Staphylococcus aureus bacteraemia were evaluated for the factors influencing prognosis. The overall episode mortality rate and the mortality rate due to bacteraemia were 43.6 and 21.8%, respectively. Episodes with methicillin-resistant S. aureus (MRSA) bacteraemia had a significantly higher overall mortality rate (58.7 vs. 30.9%, P<0.01) and mortality rate due to bacteraemia (32.6 vs. 12.7%, P=0.02) when compared with episodes caused by methicillin-sensitive S. aureus (MSSA). The multivariate analysis revealed that the underlying disease, presence of infective endocarditis, septic shock and central intravascular catheter and methicillin resistance of S. aureus were the five independent risk factors associated with a higher mortality rate.