Increased tumor growth in mice exposed to inhaled isobutyl nitrite

• Published in: Toxicology letters Vol. 104; no. 1; pp. 35 - 41
• Main Author: Soderberg, Lee S.F
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 11.01.1999; Amsterdam Elsevier Science
• Subjects: Administration, Inhalation; AIDS; Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Cell Division - drug effects; Chemical agents; Cytotoxicity; Drug addictions; Inhalants; Kaposi's sarcoma; Macrophages - drug effects; Macrophages - immunology; Medical sciences; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Nitrites - administration & dosage; Nitrites - toxicity; Sarcoma, Experimental - pathology; Stimulation, Chemical; Street Drugs - adverse effects; T-Lymphocytes, Cytotoxic - drug effects; Toxicology; Tumor; Tumor Cells, Cultured; Tumors; iNO, inducible nitric oxide; HHV-8, human herpesvirus-8; SRBC, sheep red blood cells; Inhalants; AIDS; Cytotoxicity; PFC, plaque-forming cells; KS, Kaposi's sarcoma; Kaposi's sarcoma; CTL, cytotoxic T lymphocyte; Tumor; LPS, lipopolysaccharide; IFN- γ, interferon- γ; TD, tumor dose; Cell proliferation; Immunopathology; Toxicity; Tumor promotor; Rodentia; Malignant tumor; Immune deficiency; Inhalation; Infection; Carcinogen; Kaposi sarcoma; Vertebrata; Mammalia; Mouse; Viral disease; Animal; Drug of abuse; Mechanism of action; Organic nitrite
• ISSN: 0378-4274; 1879-3169
• DOI: 10.1016/S0378-4274(98)00228-8

Epidemiological studies have correlated the incidence of Kaposi's sarcoma (KS) in AIDS with a history of abuse of nitrite inhalants. To determine if exposure to nitrite inhalants could alter tumor growth, syngeneic PYB6 tumor cells were injected into groups of mice. Exposure of these mice to inhaled isobutyl nitrite increased both the tumor incidence and the tumor growth rate by almost 4-fold. Following only five daily exposures to the inhalant, the induction of specific T cell mediated cytotoxicity was inhibited by 36%. Similar inhalation exposures inhibited the tumoricidal activity of activated macrophages by 86%. The data suggest that exposure to abuser levels of a nitrite inhalant compromised tumor surveillance mechanisms.