Drug delivery from the oral cavity: focus on a novel mechatronic delivery device

Dental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are...

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Bibliographic Details
Published inDrug discovery today Vol. 13; no. 5; pp. 247 - 253
Main Authors Scholz, Oliver A., Wolff, Andy, Schumacher, Axel, Giannola, Libero I., Campisi, Giuseppina, Ciach, Tomasz, Velten, Thomas
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.03.2008
Elsevier Science
Subjects
Administration, Buccal
Administration, Oral
Biological and medical sciences
Drug Delivery Systems - instrumentation
Drug Delivery Systems - methods
Drug Implants - administration & dosage
Drug Therapy, Computer-Assisted - instrumentation
Drug Therapy, Computer-Assisted - methods
Equipment Design
General pharmacology
Humans
Medical sciences
Mouth Mucosa - metabolism
Mouth Mucosa - physiology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Electronic control
Drug
Delivery system
Mechatronics
Pharmaceutical technology
Implant
Controlled release form
Prosthesis
Device
Mucosa
Oral cavity
Dosage form
Tooth
Miniaturization
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Summary:Dental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are rarely used. Mainly, they are focused on prophylaxis and the release of antibacterial agents. However, as buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery, and prolonged well-controlled release has been identified as beneficial, especially for chronic diseases, a new class of delivery systems is evolving: highly miniaturized computerized delivery systems, integrated into a dental appliance. Dental delivery systems today are used in two ways: the main application is the local treatment of diseases affecting the oral cavity itself like periodontitis or fungal infections. The second is for systemic drug delivery.
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ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2007.10.018