Waterhouse-Friderichsen Syndrome After Infection With Group A Streptococcus

• Published in: Mayo Clinic proceedings Vol. 76; no. 11; pp. 1167 - 1170
• Main Authors: Karakousis, Petros C., Page, Kathleen R., Varello, Michael A., Howlett, Paul J., Stieritz, Donald D.
• Format: Journal Article
• Language: English
• Published: Rochester, MN Elsevier Inc 01.11.2001; Mayo Medical Ventures; Elsevier Limited
• Subjects: Adrenal Glands - pathology; Adult; Anti-Bacterial Agents - therapeutic use; Bacterial diseases; Biological and medical sciences; Fatal Outcome; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Shock, Septic - complications; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcal Infections - complications; Streptococcus pyogenes - isolation & purification; Waterhouse-Friderichsen Syndrome - microbiology; Waterhouse-Friderichsen Syndrome - physiopathology; GAS; DIC; Endocrinopathy; Immunohistochemistry; Waterhouse Friedrichsen syndrome; Skin disease; Adrenal glands; Purpura fulminans; Cardiovascular disease; Male; Hemorrhage; Vascular disease; Pain; Streptococcal infection; Adrenal gland diseases; Evolution; Diagnosis; Sonography; Human; Radiodiagnosis; Postmortem; Fever; Infection; Case study; Symptomatology; Bacteriosis; Capillary vessel disease; Medical imagery; Death; Computerized axial tomography; Cervical spine
• ISSN: 0025-6196; 1942-5546
• DOI: 10.4065/76.11.1167

We report a case of Waterhouse-Friderichsen syndrome associated with group A streptococcus (GAS) toxic shock syndrome in a previously healthy man. The patient presented with neck pain and fevers of 2 days’ duration. Computed tomography of the neck revealed a mass in the retropharyngeal space, suggesting an abscess. Despite prompt treatment with appropriate antibiotics, the patient experienced a fulminant course and died within 8 hours of presentation. Antemortem blood cultures grew GAS positive for exotoxins A, B, and C. Postmortem examination revealed bilateral adrenal hemorrhage, consistent with Waterhouse-Friderichsen syndrome. Immunohistochemical analysis of the adrenal glands revealed the presence of GAS antigens. However, no disseminated intravascular coagulation was evident. This case demonstrates that adrenal hemorrhage can occur without associated coagulopathy and may result directly from the action of bacterial toxins.