Pathogenic mechanisms of glucocorticoid-induced osteoporosis

• Published in: Cytokine & growth factor reviews Vol. 70; pp. 54 - 66
• Main Authors: Chen, Meng, Fu, Wenyu, Xu, Huiyun, Liu, Chuan-ju
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2023
• Subjects: Glucocorticoids; Glucocorticoids - pharmacology; Humans; Osteoblast; Osteoblasts; Osteoclast; Osteoclasts; Osteocyte; Osteogenesis; Osteoporosis; Osteoporosis - chemically induced; Osteoporosis - pathology; Osteoblast; Osteoporosis; Osteoclast; Glucocorticoids; Osteocyte
• ISSN: 1359-6101; 1879-0305
• DOI: 10.1016/j.cytogfr.2023.03.002

Glucocorticoid (GC) is one of the most prescribed medicines to treat various inflammatory and autoimmune diseases. However, high doses and long-term use of GCs lead to multiple adverse effects, particularly glucocorticoid-induced osteoporosis (GIO). Excessive GCs exert detrimental effects on bone cells, including osteoblasts, osteoclasts, and osteocytes, leading to impaired bone formation and resorption. The actions of exogenous GCs are considered to be strongly cell-type and dose dependent. GC excess inhibits the proliferation and differentiation of osteoblasts and enhances the apoptosis of osteoblasts and osteocytes, eventually contributing to reduced bone formation. Effects of GC excess on osteoclasts mainly include enhanced osteoclastogenesis, increased lifespan and number of mature osteoclasts, and diminished osteoclast apoptosis, which result in increased bone resorption. Furthermore, GCs have an impact on the secretion of bone cells, subsequently disturbing the process of osteoblastogenesis and osteoclastogenesis. This review provides timely update and summary of recent discoveries in the field of GIO, with a particular focus on the effects of exogenous GCs on bone cells and the crosstalk among them under GC excess. [Display omitted] •High doses and long-term use of GCs lead to GIO.•The actions of GC excess are considered to be cell-type and dose dependent.•Impaired bone formation and increased bone resorption are the main mechanisms underlying GC-induced bone loss.•This review provides timely update and summary of recent discoveries of GIO.