Recommendations for the Use of Next-Generation Sequencing and the Molecular Tumor Board for Patients with Advanced Cancer: A Report from KSMO and KCSG Precision Medicine Networking Group

• Published in: Cancer research and treatment Vol. 54; no. 1; pp. 1 - 9
• Main Authors: Yoon, Shinkyo, Kim, Miso, Hong, Yong Sang, Kim, Han Sang, Kim, Seung Tae, Kim, Jihun, Yun, Hongseok, Yoo, Changhoon, Ahn, Hee Kyung, Kim, Hyo Song, Lee, In Hee, Kim, In-Ho, Park, Inkeun, Jeong, Jae Ho, Cheon, Jaekyung, Kim, Jin Won, Yun, Jina, Lim, Sun Min, Cha, Yongjun, Jang, Se Jin, Zang, Dae Young, Kim, Tae Won, Kang, Jin Hyoung, Kim, Jee Hyun
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.01.2022; 대한암학회
• Subjects: High-Throughput Nucleotide Sequencing - methods; High-Throughput Nucleotide Sequencing - standards; Humans; Medical Oncology - standards; Neoplasms - diagnosis; Neoplasms - genetics; Neoplasms - therapy; Practice Guidelines as Topic; Precision Medicine - methods; Republic of Korea; Societies, Medical; Special; 의학일반; Republic of Korea; Advanced solid cancer; Genomic alterations; Next-generation sequencing; Molecular tumor board; Precision Medicine
• ISSN: 1598-2998; 2005-9256; 2005-9256
• DOI: 10.4143/crt.2021.1115

Next-generation sequencing (NGS) is becoming essential in the fields of precision oncology. With implementation of NGS in daily clinic, the needs for continued education, facilitated interpretation of NGS results and optimal treatment delivery based on NGS results have been addressed. Molecular tumor board (MTB) is multidisciplinary approach to keep pace with the growing knowledge of complex molecular alterations in patients with advanced solid cancer. Although guidelines for NGS use and MTB have been developed in western countries, there is limitation for reflection of Korea’s public health environment and daily clinical practice. These recommendations provide a critical guidance from NGS panel testing to final treatment decision based on MTB discussion.