Multi-slice CT contrast-enhanced presentations of advanced gastric cancer： associations with histo-differentiation and expression of p53 and P-glycoprotein

• Published in: Chinese medical journal Vol. 121; no. 24; pp. 2487 - 2491
• Main Authors: Yin, Xin-dao, Zhao, Jian-hua, Zhang, Lin, Wang, Li-ping, Lu, Ling-quan, Wang, Li-wei, Xie, Guang-hui, Wu, Qian-zhi, Wang, Shu-zhi, Gu, Jian-ping
• Format: Journal Article
• Language: English
• Published: China Department of Radiology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210006, China%Department ot Pathology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210006, China 20.12.2008
• Subjects: Adult; Aged; Aged, 80 and over; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Female; Humans; Immunohistochemistry; Male; Middle Aged; p53表达; Stomach Neoplasms - diagnostic imaging; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Tomography, X-Ray Computed - methods; Tumor Suppressor Protein p53 - metabolism; 多层CT; 糖蛋白; multi-slice CT; P-gp; gastric cancer; p53
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/00029330-200812020-00004

Background This study aimed to investigate multi-slice CT contrast-enhanced presentation of gastric cancer and its correlation with histo-differentiation and p53 and P-glycoprotein （P-gp） expression. Methods Sixty-six patients with gastric cancer in the present study underwent a multi-slice CT preoperative routine and dual-phase contrast-enhanced examination of the upper abdomen; postoperative specimens were used to determine histo-differentiation and the expression of p53 and P-gp. The correlation of multi-slice CT contrast-enhanced presentation with histo-differentiation and expression of p53 and P-gp was analyzed. Results The dual-phase contrast-enhanced ratio （CER） was not correlated with the histo-differentiation of gastric cancer （P 〉0.05）. Positive expression of p53 and P-gp was significantly higher in the cases of layered or heterogeneous enhancement than in the cases of homogenous enhancement （P 〈0.05）. Positive expression of p53 was also correlated with the arterial phase CER, tumor size and lymph node metastasis （P 〈0.05）, but not with infiltration thickness of the gastric wall, nor was it correlated with the portal phase CER （P 〉0.05）. Positive expression of P-gp was only correlated with the portal phase CER （P=0.005）. Conclusions Differently enhanced pattern and CER of the arterial and portal phase in gastric cancer correlate with its different histo-differentiation and expression of p53 and P-gp respectively. In addition, tumor size and lymph node metastasis of gastric cancer relate to the expression of p53.