BDNF atelocollagen mini-pellet accelerates facial nerve regeneration
We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had sho...
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| Published in | Brain research Vol. 849; no. 1; pp. 235 - 238 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Elsevier B.V
04.12.1999
Amsterdam Elsevier New York, NY |
| Subjects | |
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| Abstract | We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration. |
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| AbstractList | We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration. |
| Author | Fujinaka, Toshiyuki Yuguchi, Takamichi Nakayama, Chikao Sakaki, Takayuki Sano, Akihiko Takemoto, Osamu Kishino, Akiyoshi Nonaka, Masahiro Yoshimine, Toshiki Kohmura, Eiji Koseki, Norimasa Hayakawa, Toru |
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| Keywords | Regeneration Facial nerve In situ hybridization BDNF Drug delivery system GAP-43 Vertebrata Mammalia Growth associated protein 43 Rat Rodentia Brain derived neurotrophic factor Gene expression |
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| SubjectTerms | Animals BDNF Biological and medical sciences Brain-Derived Neurotrophic Factor - administration & dosage Brain-Derived Neurotrophic Factor - pharmacology Collagen Development. Senescence. Regeneration. Transplantation Drug Carriers Drug delivery system Facial nerve Facial Nerve - drug effects Facial Nerve - physiology Facial Paralysis Female Fundamental and applied biological sciences. Psychology GAP-43 GAP-43 Protein - genetics In situ hybridization Nerve Regeneration - drug effects Nerve Regeneration - physiology Rats Rats, Wistar Regeneration RNA, Messenger - genetics Transcription, Genetic - drug effects Vertebrates: nervous system and sense organs |
| Title | BDNF atelocollagen mini-pellet accelerates facial nerve regeneration |
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