BDNF atelocollagen mini-pellet accelerates facial nerve regeneration

• Published in: Brain research Vol. 849; no. 1; pp. 235 - 238
• Main Authors: Kohmura, Eiji, Yuguchi, Takamichi, Yoshimine, Toshiki, Fujinaka, Toshiyuki, Koseki, Norimasa, Sano, Akihiko, Kishino, Akiyoshi, Nakayama, Chikao, Sakaki, Takayuki, Nonaka, Masahiro, Takemoto, Osamu, Hayakawa, Toru
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 04.12.1999; Amsterdam Elsevier; New York, NY
• Subjects: Animals; BDNF; Biological and medical sciences; Brain-Derived Neurotrophic Factor - administration & dosage; Brain-Derived Neurotrophic Factor - pharmacology; Collagen; Development. Senescence. Regeneration. Transplantation; Drug Carriers; Drug delivery system; Facial nerve; Facial Nerve - drug effects; Facial Nerve - physiology; Facial Paralysis; Female; Fundamental and applied biological sciences. Psychology; GAP-43; GAP-43 Protein - genetics; In situ hybridization; Nerve Regeneration - drug effects; Nerve Regeneration - physiology; Rats; Rats, Wistar; Regeneration; RNA, Messenger - genetics; Transcription, Genetic - drug effects; Vertebrates: nervous system and sense organs; Regeneration; Facial nerve; In situ hybridization; BDNF; Drug delivery system; GAP-43; Vertebrata; Mammalia; Growth associated protein 43; Rat; Rodentia; Brain derived neurotrophic factor; Gene expression
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(99)02163-0

We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration.