Effect of Quinupristin/Dalfopristin on Production of Cytokines by Human Monocytes

• Published in: The Journal of infectious diseases Vol. 182; no. 1; pp. 356 - 358
• Main Authors: Khan, Anis A., Slifer, Teri R., Araujo, Fausto G., Remington, Jack S.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.07.2000; University of Chicago Press; Oxford University Press
• Subjects: Adult; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Colony stimulating factors; Concise Communications; Cytokines; Cytokines - metabolism; Drug Therapy, Combination - pharmacology; Humans; In Vitro Techniques; Infections; Infectious diseases; Interleukins; Lipopolysaccharides; Male; Medical sciences; Monocytes; Monocytes - drug effects; Monocytes - metabolism; Pharmacology. Drug treatments; Staphylococcus aureus; Synercid; Tumor necrosis factors; Virginiamycin - pharmacology; Human; Monocyte; Immunomodulation; Interleukin; Cytokine; Quinupristin; In vitro; Biological activity; Dalfopristin; Antibiotic; Streptogramins; Antibacterial agent; Tumor necrosis factor α; Granulocyte macrophage colony stimulating factor
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/315655

The effect of the novel streptogramin antibiotic quinupristin/dalfopristin (synercid) on cytokine production in vitro was examined in monocytes obtained from healthy human volunteers and stimulated with either lipopolysaccharide or heat-killed Staphylococcus aureus (Pansorbin). Synercid at concentrations that are achievable in humans (1, 5, and 10 μg/mL) significantly suppressed production of interleukin (IL)-1α, IL-1β, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-α in a concentration-dependent manner. Thus, synercid possesses significant immunomodulatory activity, in addition to its antimicrobial activity.