Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids)

Abstract Total parenteral nutrition is an important adjunct in the care of neonates with surgical disorders. Cholestasis is at present the most worrisome complication of this technique; it is difficult to treat and may progress to eventual cirrhosis and liver failure. This article reviews the pertin...

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Bibliographic Details
Published inJournal of pediatric surgery Vol. 43; no. 6; pp. 1191 - 1195
Main Authors Ekema, George, Falchetti, Diego, Boroni, Giovanni, Tanca, Anna Rita, Altana, Cristian, Righetti, Laura, Ridella, Michela, Gambarotti, Marco, Berchich, Luisa
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2008
Subjects
Cholangiopancreatography, Endoscopic Retrograde
Cholecystectomy - methods
Cholestasis - etiology
Cholestasis - physiopathology
Cholestasis - therapy
Dose-Response Relationship, Drug
Drug Administration Schedule
Fish Oils - administration & dosage
Follow-Up Studies
Humans
Infant, Newborn
Intestinal Volvulus - diagnosis
Intestinal Volvulus - surgery
Liver Diseases - etiology
Liver Diseases - physiopathology
Liver Diseases - therapy
Liver Function Tests
Male
Omega-3 fatty acids
Parenteral Nutrition, Total - adverse effects
Parenteral Nutrition, Total - methods
Parenteral nutrition-associated cholestasis (PNAC)
Pediatrics
Postoperative Complications - diagnosis
Reoperation
Severity of Illness Index
Short bowel syndrome
Short Bowel Syndrome - diagnosis
Short Bowel Syndrome - etiology
Short Bowel Syndrome - therapy
Surgery
Term Birth
Treatment Outcome
Parenteral nutrition-associated cholestasis (PNAC)
Omega-3 fatty acids
Short bowel syndrome
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Summary:Abstract Total parenteral nutrition is an important adjunct in the care of neonates with surgical disorders. Cholestasis is at present the most worrisome complication of this technique; it is difficult to treat and may progress to eventual cirrhosis and liver failure. This article reviews the pertinent clinical and nutritional data in a surgical patient with short bowel syndrome who developed parenteral nutrition-associated liver disease successfully treated with fish-oil based lipids.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2008.01.005