Plasma concentrations of VEGF and bFGF in patients with gastric carcinoma

• Published in: Cancer letters Vol. 153; no. 1; pp. 7 - 12
• Main Authors: Yoshikawa, Takaki, Tsuburaya, Akira, Kobayashi, Osamu, Sairenji, Motonori, Motohashi, Hisahiko, Yanoma, Shunsuke, Noguchi, Yoshikazu
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 29.05.2000; Elsevier
• Subjects: Basic fibroblast growth factor; Biological and medical sciences; Biomarkers, Tumor - blood; Endothelial Growth Factors - blood; Female; Fibroblast Growth Factor 2 - blood; Gastric cancer; gastric carcinoma; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Lymphokines - blood; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - diagnosis; Prognosis; Prognostic factor; Stomach Neoplasms - blood; Stomach Neoplasms - diagnosis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Survival Analysis; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Prognostic factor; Basic fibroblast growth factor; Vascular endothelial growth factor; Gastric cancer; Human; Stomach; Recurrence; Carcinoma; Prognosis; Liver; Malignant tumor; Metastasis; Epidemiology; Survival; Blood plasma; Vascular endothelium growth factor; Digestive diseases; Predictive factor; Gastric disease
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(99)00426-7

We examined plasma levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in 54 patients with gastric carcinoma. Postoperative survival was significantly poorer in patients with plasma VEGF levels more than 10.0 pg/ml at the time of surgery. By an univariate analysis of the factors affecting survival, serosal invasion, lymph node metastasis, peritoneal dissemination, lymphatic vessel invasion, curability, and VEGF proteins were significant. By a multivariate analysis only VEGF levels and curability remained significant. Patients with recurrent disease, including liver metastasis, had significantly higher plasma VEGF concentrations than those with resectable primary tumors. VEGF, not bFGF, may serve as an independent prognosticator and a sensitive indicator for liver recurrence in patients with gastric carcinoma.