Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and agin...

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Published inGenes & development Vol. 20; no. 21; pp. 2913 - 2921
Main Authors Haigis, Marcia C, Guarente, Leonard P
Format Journal Article
LanguageEnglish
Published United States 01.11.2006
Subjects
Aging - genetics
Aging - metabolism
Animals
Caloric Restriction
Glucose - metabolism
Humans
Insulin - metabolism
Mice
Neurons - metabolism
Neurons - physiology
Sirtuins - physiology
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Summary:Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1467506