Transdermal iontophoresis revisited

Iontophoresis evolved as a transdermal enhancement technique in the 20th century, primarily for the delivery of large and charged molecules. Significant achievements have been made in the understanding of underlying mechanisms of iontophoresis and these have contributed to the rational development o...

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Bibliographic Details
Published inCurrent Opinion in Chemical Biology Vol. 4; no. 4; pp. 468 - 473
Main Authors Panchagnula, Ramesh, Pillai, Omathanu, Nair, Vinod B, Ramarao, Poduri
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2000
Subjects
Administration, Cutaneous
Drug formulation
Glucowatch
Humans
Iontophoresis - methods
Reverse iontophoresis
Transdermal iontophoresis
Transdermal iontophoresis
Pharmacology
Drug formulation
Reverse iontophoresis
Pharmaceutical science
Glucowatch
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Summary:Iontophoresis evolved as a transdermal enhancement technique in the 20th century, primarily for the delivery of large and charged molecules. Significant achievements have been made in the understanding of underlying mechanisms of iontophoresis and these have contributed to the rational development of iontophoretic delivery systems. The major challenges in this area are the development of portable, cost effective devices and suitable semi-solid formulations that are compatible with the device and the skin. Some of the obstacles in transdermal iontophoresis can be overcome by combining iontophoresis with other physical and chemical enhancement techniques for the delivery of macromolecules. Iontophoresis also offers an avenue for extracting information from the body through the use of reverse iontophoresis, which has potential application in diagnosis and monitoring. The current research is focussed towards resolving the skin toxicity issues and other problems in order to make this technology a commercial reality.
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ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(00)00111-3