Effect of killed whole yeast cell prebiotic supplementation on broiler performance and intestinal immune cell parameters
Two experiments were conducted to study the effect of CitriStim, a commercial killed whole yeast cell prebiotic, on broiler performance, regulatory T cells, CD4+ and CD8+ percentages, and IL-10 and IL-1 mRNA contents of the spleen and cecal tonsils. No immune challenges were imposed in either of the...
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Published in | Poultry science Vol. 91; no. 1; pp. 107 - 111 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Poultry Science Association
2012
Oxford University Press |
Subjects | |
Online Access | Get full text |
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Summary: | Two experiments were conducted to study the effect of CitriStim, a commercial killed whole yeast cell prebiotic, on broiler performance, regulatory T cells, CD4+ and CD8+ percentages, and IL-10 and IL-1 mRNA contents of the spleen and cecal tonsils. No immune challenges were imposed in either of the 2 experiments. One-day-old broiler chicks were fed a corn- and soybean meal-based diet supplemented with 0, 0.1, or 0.2% CitriStim (ADM, Decatur, IL) for 35 d. At 21 (P = 0.03) and 35 d (P = 0.02) of age, CitriStim supplementation at 0.2% increased regulatory T cell percentage in the cecal tonsil compared with that of the 0% CitriStim-supplemented group. At 21 (P = 0.08) and 35 d (P = 0.01) of age, CitriStim supplementation at 0.2% increased IL-10 mRNA content of the cecal tonsil compared with that of the 0% CitriStim-supplemented group. At 21 (P = 0.13) and 35 d (P < 0.01) of age, CitriStim supplementation at 0.2% decreased IL-1 mRNA content compared with that of the 0% CitriStim supplemented group. CitriStim supplementation did not (P > 0.05) alter the IL-10 and IL-1 mRNA contents in the spleen. CitriStim supplementation did not (P > 0.05) alter the CD4+ and CD8+ cell percentages in the spleen and cecal tonsil at 21 and 35 d of the experiment. CitriStim supplementation increased regulatory T cell percentage and IL-10 mRNA content and decreased IL-1 mRNA content in the cecal tonsil to produce a net antiinflammatory milieu. The immunomodulatory effect of CitriStim supplementation was a local effect rather than a systemic effect. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0032-5791 1525-3171 |
DOI: | 10.3382/ps.2011-01732 |