Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients

Identification of anthracycline-induced muscle loss is critical for maintaining health in adolescent and young adult (AYA) cancer patients. We used routine chest computed tomography (CT) scans to investigate changes in skeletal muscle of 16 AYA sarcoma patients at thoracic vertebrae 4 (T4) after ant...

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Bibliographic Details
Published inJournal of adolescent and young adult oncology Vol. 11; no. 3; p. 320
Main Authors Wooten, Savannah V, Roth, Michael, Livingston, John Andrew, Hildebrandt, Michelle A T, Chandra, Joya, Amini, Behrang, Kleinerman, Eugenie S, Gilchrist, Susan C
Format Journal Article
LanguageEnglish
Published United States 01.06.2022
Subjects
Adolescent
Anthracyclines - adverse effects
Humans
Muscle, Skeletal - pathology
Retrospective Studies
Sarcoma - drug therapy
Sarcoma - pathology
Sarcopenia
Soft Tissue Neoplasms - pathology
Young Adult
T4
computed tomography
muscle loss
sarcoma
anthracyclines
sarcopenia
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Summary:Identification of anthracycline-induced muscle loss is critical for maintaining health in adolescent and young adult (AYA) cancer patients. We used routine chest computed tomography (CT) scans to investigate changes in skeletal muscle of 16 AYA sarcoma patients at thoracic vertebrae 4 (T4) after anthracycline treatment. CT images were examined at three time points (prechemotherapy, postchemotherapy, and 1 year). Significant changes in total skeletal muscle index and density were seen after chemotherapy (  = 0.021 and  = 0.016, respectively) and at 1 year versus baseline (both  < 0.05). This study supports the use of T4 as an early indicator of skeletal muscle loss in AYAs.
ISSN:2156-535X
DOI:10.1089/jayao.2021.0107