A biocompatible bacterial cellulose/tannic acid composite with antibacterial and anti-biofilm activities for biomedical applications

• Published in: Materials Science & Engineering C Vol. 106; p. 110249
• Main Authors: Zhang, Zhao-Yu, Sun, Yi, Zheng, Yu-Dong, He, Wei, Yang, Ying-Ying, Xie, Ya-Jie, Feng, Zhao-Xuan, Qiao, Kun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2020; Elsevier BV
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibacterial material; Antibiotics; Bacterial cellulose composite; Biocompatibility; Biofilm; Biofilms; Biofilms - drug effects; Biomedical materials; Cellulose; Cellulose - chemistry; Composite materials; Crosslinking; E coli; Fourier transforms; Hydrogels; Incubation; Infections; Infrared spectroscopy; Inhibition; Magnesium chloride; Materials science; Metal Nanoparticles - chemistry; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Morphology; Organic chemistry; Photoelectrons; Public health; Scanning electron microscopy; Spectroscopy, Fourier Transform Infrared; Spectrum analysis; Staphylococcus aureus - drug effects; Tannic acid; Tannins - chemistry; X ray photoelectron spectroscopy; Tannic acid; Antibacterial material; Biofilm; Inhibition; Bacterial cellulose composite
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2019.110249

Biofilm-associated infections are in a high rate of recurrence and biofilms show formidable resistance to current antibiotics, making them a growing challenge in biomedical field. In this study, a biocompatible composite was developed by incorporating tannic acid (TA) and MgCl2 to bacterial cellulose (BC) for antimicrobial and anti-biofilm purposes. The morphology was investigated by scanning electron microscopy (SEM), and chemical structure were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectra (XPS). In vitro release profiles of tannic acid revealed that the Mg2+ cross-links help impede the release of TA from BC matrix, while composite BC-TA lacked Mg2+ ionic cross-links, thus more TA was released from the hydrogel. The BC-TA-Mg composites also displayed strong antibacterial activity against S. aureus, E. coli and P. aeruginosa. Moreover, the composites significantly reduced biofilm formation of S. aureus and P. aeruginosa after 24 h incubation by ∼80% and ∼87%, respectively. As a consequence, the BC-TA-Mg composites are a very promising material for combating biofilm-associated infections in biomedical and public health fields. •The novel BC-TA-Mg composites were prepared and showed good antibacterial activity.•Incorporation of tannic acid endowed the composites with strong anti-biofilm activity.•Incorporation of Mg2+ ions into composites significantly improved biocompatibility.•The prepared composites are promising materials for biomedical applications.