The expression of podoplanin is associated with poor outcome in cutaneous squamous cell carcinoma

• Published in: Journal of cutaneous pathology Vol. 44; no. 2; pp. 144 - 151
• Main Authors: Cañueto, Javier, Cardeñoso‐Álvarez, Ester, Cosano‐Quero, Adriana, Santos‐Briz, Ángel, Fernández‐López, Emilia, Pérez‐Losada, Jesús, Román‐Curto, Concepción
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2017; Wiley Subscription Services, Inc
• Subjects: Biomarkers, Tumor - analysis; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; cutaneous squamous cell carcinoma; D2‐40; Disease-Free Survival; Female; Humans; Immunohistochemistry; Invasiveness; Latency; Male; Medical prognosis; Membrane Glycoproteins - analysis; Membrane Glycoproteins - biosynthesis; Metastases; podoplanin; Prognosis; Skin Neoplasms - mortality; Skin Neoplasms - pathology; Squamous cell carcinoma; Tissue Array Analysis; cutaneous squamous cell carcinoma; podoplanin; prognosis; D2-40
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.12859

Background Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and can be both locally invasive and metastatic at distant sites. While research efforts have been made to predict poor outcome of CSCC, there is a lack of knowledge regarding molecular markers. Podoplanin has been associated with poor outcome in several types of cancer including CSCC, but this is controversial and only a few studies have evaluated the prognostic implications of podoplanin in the development of this tumor. Methods We evaluated podoplanin expression in a series of 94 CSCCs, and searched for associations between podoplanin expression and histopathological characteristics and with events of poor clinical evolution of the disease. Results Podoplanin expression was observed in 48.9% of the cases and the expression was considered moderate to intense in 19 of the cases. Moderate/intense podoplanin was associated with infiltrative growth pattern, desmoplasia, lymphovascular invasion, higher risk of nodal progression (NP) and short disease‐free survival, specifically with a short latency to NP. Conclusions This article provides evidence supporting the implication of podoplanin expression as a marker of bad prognosis of CSCC.