Deep intrastromal bevacizumab injection for management of corneal stromal vascularization after deep anterior lamellar keratoplasty, a novel technique

• Published in: Cornea Vol. 30; no. 2; p. 215
• Main Authors: Hashemian, Mohammad Naser, Zare, Mohammad Ali, Rahimi, Firoozeh, Mohammadpour, Mehrdad
• Format: Journal Article
• Language: English
• Published: United States 01.02.2011
• Subjects: Angiogenesis Inhibitors - administration & dosage; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal, Humanized; Bevacizumab; Corneal Neovascularization - etiology; Corneal Neovascularization - pathology; Corneal Stroma - blood supply; Corneal Transplantation - adverse effects; Corneal Transplantation - methods; Humans; Injections, Intraocular; Male; Treatment Outcome; Visual Acuity - drug effects; Young Adult
• ISSN: 1536-4798
• DOI: 10.1097/ico.0b013e3181e291a6

To report the effect of intrastromal injection of bevacizumab in an eye with extensive corneal stromal vascularization after deep anterior lamellar keratoplasty. Bevacizumab (2.5 mg/1 mL) was injected into the deep corneal stroma of an eye with severe and extensive stromal vascularization. Corneal vascularization regressed dramatically after deep stromal injection of bevacizumab with no recurrence after 6 months. Visual acuity was improved, and the patient's complaints subsided. Corneal intrastromal injection of bevacizumab can be considered for management of intrastromal vascularization after deep anterior lamellar keratoplasty.