Detection of experimental rat liver tumors by contrast-assisted ultrasonography

The authors characterized the effect of intravenous lipid-coated microbubbles (LCMs) on the echogenicity of malignant liver tumors. Novikoff hepatoma cells were inoculated into the livers of 16 anesthetized Sprague-Dawley rats. Sonograms were obtained weekly after tail-vein injection with either 0.2...

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Bibliographic Details
Published inInvestigative radiology Vol. 28; no. 3; p. 218
Main Authors D'Arrigo, J S, Ho, S Y, Simon, R H
Format Journal Article
LanguageEnglish
Published United States 01.03.1993
Subjects
Animals
Contrast Media
Lipids
Liver Neoplasms, Experimental - diagnostic imaging
Male
Microspheres
Neoplasm Transplantation
Rats
Rats, Sprague-Dawley
Ultrasonography
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Summary:The authors characterized the effect of intravenous lipid-coated microbubbles (LCMs) on the echogenicity of malignant liver tumors. Novikoff hepatoma cells were inoculated into the livers of 16 anesthetized Sprague-Dawley rats. Sonograms were obtained weekly after tail-vein injection with either 0.2 mL/kg LCMs or saline control. A statistically significant difference in the signal-to-noise ratio (SNR) was observed between the group that received LCMs (10 rats) and the group that received saline (6 rats) (P < .01). The effect persisted for 30 minutes after contrast injection. Selective leakage and accumulation of LCMs into the tumor tissue itself was confirmed histologically using lipid-specific counterstains. Intravenous injection of the LCM contrast agent produces a rapid increase in the echogenicity of the experimental Novikoff tumor in the rat liver.
ISSN:0020-9996
DOI:10.1097/00004424-199303000-00006