Neocryptolepine (Cryprotackieine), A Unique Bioactive Natural Product: Isolation, Synthesis, and Profile of Its Biological Activity

The widely varying different approaches to the total synthesis of the indoloquinoline alkaloid neocryptolepine are discussed. Aspects relating to the isolation of the natural product from Cryptolepis sanguinolenta, as well as its performance in various biological tests and spectroscopic studies invo...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 2014; no. 36; pp. 7979 - 8003
Main Authors Bracca, Andrea B. J., Heredia, Daniel A., Larghi, Enrique L., Kaufman, Teodoro S.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.12.2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Alkaloids
Cyclization
Medicinal chemistry
Natural products
Nitrogen heterocycles
Total synthesis
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Summary:The widely varying different approaches to the total synthesis of the indoloquinoline alkaloid neocryptolepine are discussed. Aspects relating to the isolation of the natural product from Cryptolepis sanguinolenta, as well as its performance in various biological tests and spectroscopic studies involving the natural product, are also reviewed. Neocryptolepine is an indoloquinoline alkaloid, isolated from Cryptolepis sanguinolenta. The isolation of the natural product and the numerous and different approaches directed towards its total synthesis, as well as its biological activity profile and spectroscopic studies, are discussed.
Bibliography:ArticleID:EJOC201402910
istex:7664BA9C0E01B90323A9347400702D03862B9475
ark:/67375/WNG-D9JGKVBG-K
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201402910