THE ROUND LIGAMENT IN DEVELOPMENTAL HIP DYSPLASIA: ARE ITS MECHANICAL AND HISTOLOGICAL PROPERTIES PRESERVED?

During open surgical dislocated hip reduction, several anatomical structures, such as the round ligament, are approached. However, there is controversy over both the possibility of preserving the ligament and its functional importance. This experimental study used skeletally immature rabbits as a mo...

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Published inActa ortopedica brasileira Vol. 30; no. 1; p. e235808
Main Authors Zuccon, Alexandre, Pereira, Hamilton DA Rosa, Santos, Sérgio Alexandre Alcântara Dos, Felisbino, Sérgio Luís, Junior, Luís Antônio Justulin, Cataneo, Daniele Cristina
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil ATHA EDITORA 01.01.2022
Sociedade Brasileira de Ortopedia e Traumatologia
Subjects
Collagen
Hip dislocation
Models, animal
Original
ORTHOPEDICS
Rabbits
Round ligaments
Rabbits
Round ligaments
Models, animal
Hip dislocation
Collagen
Colágeno
Coelhos
Modelos animais
Luxação do quadril
Ligamentos redondos
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Summary:During open surgical dislocated hip reduction, several anatomical structures, such as the round ligament, are approached. However, there is controversy over both the possibility of preserving the ligament and its functional importance. This experimental study used skeletally immature rabbits as a model for congenital hip dislocation. Thirty-six rabbits comprised the sample that was submitted to the round ligament analysis. The sample was stratified for analysis (biomechanics, zymography, histology, and immunohistochemistry). Statistical analysis compared the unstable side to the control side of each rabbit. Biomechanical assays showed that the mean maximal strength of the round ligament on the unstable side was similar to that of the control side (p = 0.594), which was also the case with maximum deformation (p = 0.328). Histologically, there was a statistically significant increase in cellularity on the unstable side (p <0.001). Additionally, there was significantly greater collagen occupancy on the control side (p <0.001). Zymography revealed no significant difference in the amount of active metalloproteinase 2 (MMP-2) (p = 0.068). Although histological analysis found evidence of significant changes in the RL in unstable hips, there were no significant differences in zymography, and no changes were observed in biomechanical tests.
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AUTHORS’ CONTRIBUTION: Each author contributed individually and significantly to the development of this article. AZ: Conceptualization, formal analysis, Investigation, Methodology, project administration, writing - original draft e writing - review. HRP: conceptualization, supervision, writing – review. SAAS: Methodology, investigation, software. SLF and LAJJ: Resources e methodology. DCC: Supervision, data curation e validation, writing – review.
ISSN:1413-7852
1809-4406
1809-4406
DOI:10.1590/1413-785220223001e235808