The Role of Prophylactic Antibiotics After Minimally Invasive Pyeloplasty With Ureteral Stent Placement in Children

• Published in: Urology (Ridgewood, N.J.) Vol. 89; pp. 107 - 112
• Main Authors: Ferroni, Matthew C, Lyon, Timothy D, Rycyna, Kevin J, Dwyer, Moira E, Schneck, Francis X, Ost, Michael C, Cannon, Glenn M, Stephany, Heidi A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2016
• Subjects: Adolescent; Antibiotic Prophylaxis; Child; Child, Preschool; Female; Humans; Kidney Pelvis - surgery; Laparoscopy; Male; Minimally Invasive Surgical Procedures; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Retrospective Studies; Robotic Surgical Procedures; Stents; Ureter; Urinary Tract Infections - epidemiology; Urinary Tract Infections - etiology; Urinary Tract Infections - prevention & control; Urologic Surgical Procedures - methods; Urology
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2015.11.035

Objective To determine whether children discharged with prophylactic antibiotics following laparoscopic pyeloplasty with indwelling ureteral stent have a decrease risk of postoperative urinary tract infections (UTIs) compared to those discharged without antibiotics. Materials and Methods A retrospective review of all minimally invasive pyeloplasties performed at our institution from January 2009 to March 2015 was conducted. Patients were discharged home with or without daily prophylactic-dose antibiotics continued until 3 days after ureteral stent removal per surgeon preference. The primary outcome was incidence of culture-positive UTI. Secondary outcomes included bacteriuria at time of stent removal and adverse events associated with extended antibiotic therapy. Results Of 163 pyeloplasties (106 robotic and 57 pure laparoscopic) performed over the study period, 126 patients were discharged on prophylactic antibiotics whereas 37 patients were discharged without prophylaxis. Groups were different with respect to median age (7.1 vs 12.0 years, P  = .03) and median duration of ureteral stent (35 days vs 28 days, P  = .02). The incidence of culture-positive UTI between the time of discharge and stent removal was comparably low between groups; 2/126 (1.6%) in the prophylaxis group and 1/37 (2.7%) in the group not on prophylaxis. At time of stent removal, perioperative urine culture was positive in 2/20 (10.0 %) patients who received prophylactic antibiotics and in 1/25 (4.0%) patients who did not ( P  = .54). Conclusion The administration of extended prophylactic antibiotics showed no significant impact on the rate of UTI following minimally invasive pyeloplasty.