Proteolytic ratchets that control progression through mitosis

A key player in mitotic progression is a cell-cycle-regulated ubiquitin–protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase–anaphase transition by mediating the ubiquitin-dependent destruction of anaphase...

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Bibliographic Details
Published inTrends in cell biology Vol. 8; no. 6; pp. 238 - 244
Main Authors Townsley, Fiona M, Ruderman, Joan V
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.1998
Subjects
anaphase
Anaphase-Promoting Complex-Cyclosome
APC/C
cell cycle
checkpoint
cyclin
destruction
Fungal Proteins - physiology
Ligases - physiology
mitosis
Mitosis - physiology
proteolysis
ubiquitin
Ubiquitin-Protein Ligase Complexes
Ubiquitin-Protein Ligases
Ubiquitins - physiology
Yeasts - cytology
Yeasts - enzymology
checkpoint
APC/C
cyclin
cell cycle
anaphase
mitosis
destruction
proteolysis
ubiquitin
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Summary:A key player in mitotic progression is a cell-cycle-regulated ubiquitin–protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase–anaphase transition by mediating the ubiquitin-dependent destruction of anaphase inhibitors and initiates exit from mitosis by degrading mitotic cyclins. This review describes the known components and substrates of the mitotic ubiquitination machinery and discusses how a new subfamily of proteins that contain the WD40 repeat (the Fizzy/Cdc20p family) might activate the APC/C to allow temporal differences in substrate ubiquitination during progression through mitosis.
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ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(98)01268-9